The municipality of San Donaci is 23 km from the city of Brindisi, 130 km from the Bari-Rome and Bari-Bologna freeways and 50 km from Taranto, from where the A3 Salerno-Reggio Calabria freeway can be reached.
The nearest FF SS station is San Pietro Vernotico on the Lecce-Rome and Lecce-Milan line and is 8 km from San Donaci. The nearest airport is Brindisi, which is 23 km away.